Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
Check out the top footballers of the weekend...
Roma came from behind to beat Real Madrid while Chelsea were held in Tuesday night's Champions League matches.
Struggling Rayo win at Valladolid after late penalty save
Barcelona put one foot in the Champions League last 16 with a 5-0 away drubbing of Basel and are the only team with a 100 percent record.
News of all that's transpired on and off the football field.
Jose Mourinho said on Sunday that he intends to return to the Premier League when his time as Inter Milan coach comes to an end.
News of all that's transpired on and off the football field
AC Milan went out of the Italian Cup after being held 1-1 at Catania, while AS Roma crushed Torino 4-0 to reach the quarter-finals.
Cristiano Ronaldo was booed by Real Madrid fans despite grabbing one goal and laying on another in their 2-0 Champions League last-16 second leg win over AS Roma on Tuesday.
Images from the Champions League matches played on Wednesday
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
AC Milan striker Marco Borriello has been suspended after testing positive in a routine doping test.
Captain Paul Pogba produced an outstanding performance garnished by two goals to help Manchester United to a resounding 3-0 win at Swiss debutants Young Boys Bern in their Champions League Group H opener on Wednesday.
Two supporters were kept in overnight and a local hospital spokesman said one fan had suffered stomach wounds as 10-man United lost their quarter-final, first leg 2-1.
Manchester United and Chelsea will both be putting their quests for domestic dominance to one side on Wednesday and turning their attentions instead to European glory.
Chelsea also got their Champions League campaign off to a good start, beating Werder Bremen 2-0.
'So, the Champions League final will be played between two teams who just don't know when they are beaten,' says Suhit K Sen.
Zlatan Ibrahimovic scored a dubious penalty as 10-man Inter Milan beat second-from-bottom Empoli 1-0 on Sunday to pull eight points clear at the top of Serie A.
The Premier League leaders will be without Rio Ferdinand, Gary Neville, Nemanja Vidic and Mikael Silvestre for their Champions League semi-final against Inter Milan.
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AS Roma captain Francesco Totti has warned Manchester United coach Alex Ferguson not to underestimate him when their two sides play the first leg of their Champions League quarter-final next week.
Italy will even be back to four teams in the Champions League group stage this season -- although that is thanks to a controversial re-formulation of the competition by UEFA rather than a significant improvement in performances by Serie A clubs.
Major world record deals are here.
Barcelona went out of the Champions League in the first knockout phase on the away goals rule despite a 1-0 win over Liverpool.
Everyone at Manchester City is flying high after the 1-0 derby win over Manchester United at the weekend but they could all come crashing back to earth after Wednesday's meeting with CSKA Moscow in the Champions League.
Inter Milan notched up their 17th successive Serie A victory with a 5-2 win at Catania on Sunday.
Holders Real Madrid reached the Champions League final for a third year in a row after taking advantage of Bayern Munich's carelessness in attack and defence to draw 2-2 in their semi-final second leg on Tuesday, and winning 4-3 on aggregate, at the Santiago Bernabeu, in Madrid, Spain, on Tuesday.
A round-up of Wednesday's Champions League first knockout round, first leg ties.
The swimmers led India's charge on Saturday by winning 7 gold, 1 silver and 1 bronze as they completely dominated the pool yet again.
Holders Real Madrid came from a goal down to snatch a precious 2-1 victory at wasteful Bayern Munich on Wednesday and carry a considerable advantage into their Champions League semi-final second leg in Spain.
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Juventus coach Massimiliano Allegri has confirmed that the Serie A leaders are interesting in signing Dutch midfielder Wesley Sneijder from Galatasaray.
champions Inter Milan are now three points clear at the top of Serie A with 17 points from seven games courtesy of their 2-1 win over Napoli.
Inter Milan extended their lead at the top of Serie A to four points when Patrick Vieira scored the winner in a 2-1 victory at Palermo.
Senad Lulic scored a late goal to give Lazio a 1-0 win at Napoli which sent them into the Coppa Italia final and added to Rafael Benitez's problems on Wednesday.
Cristiano Ronaldo showed nerves of steel to score an injury-time penalty and send holders Real Madrid into the semi-finals of the Champions League in extraordinary circumstances as they lost 3-1 to Juventus on Wednesday but won a thrilling tie 4-3 on aggregate.
News of all that's transpired on and off the football field
News of all that transpired on and off the football field on Friday
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